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Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder
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Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder
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Journal Article
Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder
2017
Overview
Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis of autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand how gut dysbiosis and related alterations may contribute to autistic phenotype. In this study we paralleled gut microbiota (GM) profiles, behavioral characteristics, intestinal integrity and immunological features of colon tissues in BTBR T + tf/J (BTBR) inbred mice, a well established animal model of ASD. Sex differences, up to date poorly investigated in animal models, were specifically addressed. Results showed that BTBR mice of both sexes presented a marked intestinal dysbiosis, alterations of behavior, gut permeability and immunological state with respect to prosocial C57BL/6j (C57) strain. Noticeably, sex-related differences were clearly detected. We identified
Bacteroides, Parabacteroides, Sutterella, Dehalobacterium
and
Oscillospira
genera as key drivers of sex-specific gut microbiota profiles associated with selected pathological traits. Taken together, our findings indicate that alteration of GM in BTBR mice shows relevant sex-associated differences and supports the use of BTBR mouse model to dissect autism associated microbiota-gut-brain axis alteration.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/77
/ 64/60
/ Animals
/ Autism
/ Autism Spectrum Disorder - metabolism
/ Autism Spectrum Disorder - pathology
/ Bacteria - isolation & purification
/ Colon
/ Female
/ Humanities and Social Sciences
/ Male
/ Mice
/ RNA, Ribosomal, 16S - chemistry
/ RNA, Ribosomal, 16S - genetics
/ RNA, Ribosomal, 16S - metabolism
/ Rodents
/ Science
