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Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet
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Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet
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Journal Article
Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet
2015
Overview
Obesity is a multifactorial health problem resulting from genetic, environmental and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. Mice were divided into three groups: normal diet (ND), HFD-obesity prone (HFD-OP) and HFD-obesity resistant (HFD-OR). Principal components analyses showed a difference between the HFD-OP and HFD-OR groups. Individuals in the HFD-OR group were closer to those in the ND group compared with those in the HFD-OP group. In particular, phosphocholine (PC) and triglyceride (TG) levels differed significantly depending on the length of the acyl chain and degree of unsaturation, respectively. PC species were either positively or negatively correlated with concentrations of glucose, insulin, leptin and hepatic cholesterol according to the length of the acyl chain. Decreased expression of the scavenger receptor B1 and ATP-binding cassette A1 in HFD-OP mice indicated that the acyl chain length of PC species may be related to high-density lipoprotein cholesterol metabolism. This study demonstrates that lipidomic profiling is an effective approach to analyzing global lipid alterations as they pertain to obesity.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 64/60
/ Animals
/ ATP Binding Cassette Transporter 1 - genetics
/ ATP Binding Cassette Transporter 1 - metabolism
/ Chromatography, High Pressure Liquid
/ Diet
/ Diet, High-Fat - adverse effects
/ Humanities and Social Sciences
/ Insulin
/ Leptin
/ Liver
/ Male
/ Mice
/ Obesity
/ Phosphorylcholine - metabolism
/ Principal Component Analysis
/ Rodents
/ Scavenger Receptors, Class B - genetics
/ Scavenger Receptors, Class B - metabolism
/ Science
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
