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Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
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Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
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Journal Article
Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
2016
Overview
Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics and increases therapeutic resistance. However, the mechanisms that facilitate the functions of Twist remain unclear. Here we report that Twist overexpression increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1 promotes invasion, migration and CSC-like properties in breast cancer by activating the transcriptional co-activator TAZ. Our study indicates that Hippo pathway inhibition is required for the increased migratory and invasiveness ability of breast cancer cells in Twist-mediated EMT.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/35
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Epithelial-Mesenchymal Transition - genetics
/ Female
/ Humanities and Social Sciences
/ Humans
/ Protein-Serine-Threonine Kinases - metabolism
/ Science
/ Snail Family Transcription Factors - genetics
/ Snail Family Transcription Factors - metabolism
