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Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

by Yau, Linda , Mekebeb-Reuter, Martha , Criner, Gerard J , Baden, Rachel , González-Lara, Maria F , Cameron, Miriam L , Reiss, William G , Han, Jian , Neidhart, Jeffrey D , Salama, Carlos , Garcia-Diaz, Julia , Shah, Reena , Mohan, Shalini V , Pandit, Lavannya , Kaplan-Lewis, Emma , Assman, Beverly , Chávez, Victoria , Lima de Menezes, Ferdinando , Freedman, Jamie , Kramer, Benjamin

in Adult / Adverse events / Age / Aged / Antibodies, Monoclonal, Humanized - therapeutic use / Body weight / Clinical trials / Coronaviruses / COVID-19 / COVID-19 - drug therapy / COVID-19 - ethnology / COVID-19 - mortality / Cytokines / Death / Disease Progression / Female / Hispanic Americans / Hospitalization / Humans / Immunosuppressive agents / Infections / Intention to Treat Analysis / Interleukin 6 / Male / Mechanical ventilation / Middle Aged / Minority & ethnic groups / Monoclonal antibodies / Mortality / Original / Patient safety / Placebos / Pneumonia / Pneumonia, Viral - drug therapy / Respiration, Artificial / Respiratory distress syndrome / Safety / Severe acute respiratory syndrome coronavirus 2 / Site selection / Survival Rate / Ventilators

2021

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Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

2021

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Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

2021

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Journal Article

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

Yau, Linda,

Mekebeb-Reuter, Martha,

Criner, Gerard J,

Baden, Rachel,

González-Lara, Maria F,

Cameron, Miriam L,

Reiss, William G,

Han, Jian,

Neidhart, Jeffrey D,

Salama, Carlos,

Garcia-Diaz, Julia,

Shah, Reena,

Mohan, Shalini V,

Pandit, Lavannya,

Kaplan-Lewis, Emma,

Assman, Beverly,

Chávez, Victoria,

Lima de Menezes, Ferdinando,

Freedman, Jamie,

Kramer, Benjamin

2021

Overview

In a randomized trial, the risk of mechanical ventilation or death among patients hospitalized with Covid-19 pneumonia (56.0% Hispanic or Latino, 14.9% Black, and 12.7% American Indian or Alaska Native) was 12.0% in the tocilizumab group and 19.3% in the placebo group. Tocilizumab did not increase survival.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Adverse events

/ Age

/ Aged

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Body weight

/ Clinical trials