Asset Details
Do you wish to reserve the book?
Human papillomavirus and human telomerase RNA component gene in cervical cancer progression
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Human papillomavirus and human telomerase RNA component gene in cervical cancer progression
Do you wish to request the book?
Human papillomavirus and human telomerase RNA component gene in cervical cancer progression
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Human papillomavirus and human telomerase RNA component gene in cervical cancer progression
2019
Overview
This study aimed to examine hTERC gene in different grades of cervical intraepithelial neoplasia (CIN) and cervical cancer, and the association between hTERC and high risk-human papillomavirus (HR-HPV) infection. Patients who underwent cervical cancer screening at the Second Affiliated Hospital of Kunming Medical University between October 2010 and December 2011 were enrolled. All patients underwent liquid-based cytology test and hybrid capture 2 (HC2) for HPV detection. hTERC was examined using fluorescence
in situ
hybridization (FISH). Cervical colposcopy biopsy was performed if any of the three results was positive. HC2, FISH, and pathology were compared. A total of 1200 women underwent screening, 150 patients underwent cervical biopsy: 32 in the normal group, 38 in the CIN1 group, 66 in the CIN2/3 group, and 14 in the invasive cervical cancer group. More patients had HR-HPV infection in the CIN2/3 group and ICC group compared with the CIN1 group. hTERC increased with increasing histological dysplasia. There was significant difference in hTERC positive rate between each of the three groups. More patients with hTERC gene amplification were observed in the positive HR-HPV group than in the HR-HPV negative group. In conclusion, hTERC is a potential marker for precancerous cervical cancer lesions. hTERC might be correlated with HR-HPV infection in cervical diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/4028
/ 692/699
/ Biopsy
/ Cervical Intraepithelial Neoplasia - complications
/ Cervical Intraepithelial Neoplasia - pathology
/ Cervical Intraepithelial Neoplasia - virology
/ Cervix
/ Cytology
/ Female
/ Fluorescence in situ hybridization
/ Humanities and Social Sciences
/ Humans
/ In Situ Hybridization, Fluorescence
/ Nucleic Acid Amplification Techniques
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - pathology
/ Patients
/ RNA
/ Science
/ Uterine Cervical Neoplasms - genetics
