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Neurostimulation for Parkinson's Disease with Early Motor Complications

by Raoul, S , Fink, G.R , Hartmann, A , Knudsen, K , Houeto, J.-L , Wojtecki, L , Régis, J.-M , Volkmann, J , Thobois, S , Bataille, B , Sixel-Doering, F , Mehdorn, M , Ory-Magne, F , Kloss, M , Navarro, S.M , Seigneuret, E , Hellwig, D , Brefel Courbon, C , Deuschl, G , Gharabaghi, A , Vesper, J , Damier, P , Paschen, S , Agid, Y , Kupsch, A , Schnitzler, A , Schneider, G.-H , Schuepbach, W.M.M , Barbe, M.T , Krack, P , Gruber, D , Pinsker, M.O , Oertel, W.H , Maarouf, M , Witjas, T , Chaynes, P , Mertens, P , Speelman, H , Krüger, R , Maltête, D , Amtage, F , Post, B , Rau, J , Falk, D , Timmermann, L , Hesekamp, H , Kistner, A , Schade-Brittinger, C , Hälbig, T.D , Meier, N

in Activities of Daily Living / Adult / Adult and adolescent clinical studies / Antiparkinson Agents - adverse effects / Antiparkinson Agents - therapeutic use / Basal ganglia / Biological and medical sciences / Central nervous system diseases / Combined Modality Therapy / Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases / Dopamine Agonists - adverse effects / Dopamine Agonists - therapeutic use / Dyskinesia / Dyskinesias - etiology / Electric Stimulation Therapy - adverse effects / Female / General aspects / Health care / Humans / Implantable Neurostimulators - adverse effects / Intention to Treat Analysis / Levodopa / Male / Medical sciences / Middle Aged / Mobility / Movement disorders / Neurodegenerative diseases / Neurology / Organic mental disorders. Neuropsychology / Parkinson Disease - drug therapy / Parkinson Disease - physiopathology / Parkinson Disease - therapy / Parkinson's disease / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Quality of Life / Subthalamic Nucleus / Surveys and Questionnaires / Treatment Outcome

2013

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Neurostimulation for Parkinson's Disease with Early Motor Complications

2013

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2013

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Journal Article

Neurostimulation for Parkinson's Disease with Early Motor Complications

Raoul, S,

Fink, G.R,

Hartmann, A,

Knudsen, K,

Houeto, J.-L,

Wojtecki, L,

Régis, J.-M,

Volkmann, J,

Thobois, S,

Bataille, B,

Sixel-Doering, F,

Mehdorn, M,

Ory-Magne, F,

Kloss, M,

Navarro, S.M,

Seigneuret, E,

Hellwig, D,

Brefel Courbon, C,

Deuschl, G,

Gharabaghi, A,

Vesper, J,

Damier, P,

Paschen, S,

Agid, Y,

Kupsch, A,

Schnitzler, A,

Schneider, G.-H,

Schuepbach, W.M.M,

Barbe, M.T,

Krack, P,

Gruber, D,

Pinsker, M.O,

Oertel, W.H,

Maarouf, M,

Witjas, T,

Chaynes, P,

Mertens, P,

Speelman, H,

Krüger, R,

Maltête, D,

Amtage, F,

Post, B,

Rau, J,

Falk, D,

Timmermann, L,

Hesekamp, H,

Kistner, A,

Schade-Brittinger, C,

Hälbig, T.D,

Meier, N

2013

Overview

In this 2-year trial involving patients with Parkinson's disease and early motor complications, subthalamic stimulation plus medical therapy resulted in better quality of life and motor function than medical therapy alone. Parkinson's disease is a progressive neurodegenerative disease that affects dopaminergic neurotransmission, resulting in bradykinesia, rigidity, and rest tremor. After an initial honeymoon period, during which there is a sustained response to dopaminergic treatment, beneficial effects are hampered by levodopa-induced motor complications, 1 progressively compromising quality of life. 2 – 4 Because levodopa-responsive parkinsonian symptoms are improved by high-frequency stimulation of the subthalamic nucleus, 5 , 6 neurostimulation has become an established treatment for advanced Parkinson's disease with medically intractable fluctuations and dyskinesia 7 – 10 and has shown long-term efficacy. 11 – 13 It is typically used after the disease has been present for 11 to 13 years, 7 – . . .

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Publisher

Massachusetts Medical Society

Subject

Activities of Daily Living

/ Adult

/ Adult and adolescent clinical studies

/ Antiparkinson Agents - adverse effects

/ Antiparkinson Agents - therapeutic use

/ Basal ganglia

/ Biological and medical sciences