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Subtypes of P2 Receptors in Rat Neuromuscular Junction
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Journal Article
Subtypes of P2 Receptors in Rat Neuromuscular Junction
2025
Overview
At the neuromuscular junction, ATP and its metabolite adenosine regulate the release of acetylcholine by activating purinergic receptors (P2), thereby regulating the function of skeletal muscles under normal and pathological conditions. The presence of P2 receptors in the neuromuscular junction was assessed immunohistochemically on sections of
m. soleus
,
m. extensor digitorum longus
, and diaphragm muscle. Of the ionotropic P2X receptors, P2X1 and P2X2 subtypes showed high expression in the studied samples. Among the P2Y receptor family, only the P2Y13 subtype was expressed in the sections. This study provides new insight into the subtypes of purinergic receptors involved in controlling the cholinergic transmission in the mammalian neuromuscular system
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Adenosine Triphosphate - metabolism
/ Animals
/ Biomedical and Life Sciences
/ Male
/ Muscle, Skeletal - metabolism
/ Muscles
/ Neuromuscular Junction - metabolism
/ Rats
/ Receptors, Purinergic P2 - metabolism
/ Receptors, Purinergic P2X - metabolism
/ Receptors, Purinergic P2X1 - genetics
/ Receptors, Purinergic P2X1 - metabolism
/ Receptors, Purinergic P2X2 - genetics
/ Receptors, Purinergic P2X2 - metabolism
/ Synapses
