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Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model
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Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model
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Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model
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Journal Article
Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model
2015
Overview
Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date, the creation of which would aid in understanding this complex disease. Here we demonstrate that early-life consumption of a moderately malnourished diet, in combination with iterative oral exposure to commensal Bacteroidales species and
Escherichia coli
, remodels the murine small intestine to resemble features of EE observed in humans. We further report the profound changes that malnutrition imparts on the small intestinal microbiota, metabolite and intraepithelial lymphocyte composition, along with the susceptibility to enteric infection. Our findings provide evidence indicating that both diet and microbes combine to contribute to the aetiology of EE, and describe a novel murine model that can be used to elucidate the mechanisms behind this understudied disease.
Environmental enteropathy is a disorder of the small intestine that contributes to the persistence of childhood malnutrition worldwide. Here, Brown
et al
. show in mice that early-life malnourishment, in combination with exposure to commensal bacteria, remodels the small intestine to resemble features of the disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 14/32
/ 38/1
/ 64/60
/ 82/58
/ Animals
/ Diet
/ E coli
/ Etiology
/ Female
/ Growth
/ Humanities and Social Sciences
/ Intestinal Diseases - metabolism
/ Intestinal Diseases - microbiology
/ Intestine, Small - metabolism
/ Intestine, Small - microbiology
/ Intestine, Small - physiopathology
/ Malnutrition - physiopathology
/ Proteins
/ Science
