Asset Details
Do you wish to reserve the book?
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide
Do you wish to request the book?
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide
2015
Overview
Tamoxifen is a selective oestrogen receptor modulator widely used for the treatment of breast cancer. In addition to its activity as an oestrogen receptor agonist/antagonist, tamoxifen also modulates sphingolipid biosynthesis, which has been shown to play an important role in the regulation of neutrophil activity. Here, we find that tamoxifen stimulation enhances several pro-inflammatory pathways in human neutrophils, including chemotaxis, phagocytosis and neutrophil extracellular trap (NET) formation. The enhancement of NET production occurs via a ceramide/PKCζ-mediated pathway, and treatment with synthetic ceramide is sufficient to promote NET formation. Pretreatment of human neutrophils with tamoxifen boosts neutrophil bactericidal capacity against a variety of pathogens
in vitro
and enhances clearance of the leading human pathogen methicillin-resistant
Staphylococcus aureus in vivo
. Our results suggest that tamoxifen, and the lipid signalling pathways it modulates, merit further exploration as targets for boosting host innate immune function.
Tamoxifen, widely used to modulate oestrogen receptor activity in breast cancer treatment, also regulates sphingolipid metabolism. Here the authors show that the latter activity of tamoxifen stimulates pro-inflammatory and antibacterial activities of human neutrophils.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/1
/ 13/106
/ 13/51
/ 14
/ 14/63
/ 59
/ 64
/ 64/60
/ 692/308
/ 82
/ 96
/ Animals
/ Extracellular Traps - drug effects
/ Female
/ Humanities and Social Sciences
/ Humans
/ Immunity, Innate - drug effects
/ Methicillin-Resistant Staphylococcus aureus
/ Mice
/ Protein Kinase C - metabolism
/ Science
