Journal Article

The genetics of osteoporosis: vitamin D receptor polymorphisms

Fleet, J.C, Wood, R.J. (Tufts University, Boston, MA.)

1998

Overview

Osteoporosis is a metabolic bone disease characterized by low bone mass and deterioration of bone tissue that leads to bone fragility and an increase in fracture risk. It is a disease with a complex etiology that includes genetic and environmental contributors. Environmental factors that influence bone density include dietary factors--such as intakes of calcium, alcohol, and caffeine--and lifestyle factors--such as exercise and smoking. Ethnic differences in the propensity to nontraumatic bone fracture suggest that genetic factors are important. Recently, common allelic variations in the vitamin D receptor gene have been found to be associated with bone mineral density in racially diverse population groups, as well as in prepubertal girls, young adult and postmenopausal women, and men. However, many studies have not been able to find this association. Additional approaches, such as sib-pair analysis, will probably be necessary in the future to identify the important genetic determinants of osteoporosis

• Publisher: Annual Reviews,Annual Reviews, Inc
• Subject: ABSORCION / ABSORCION DIGESTIVA / ABSORPTION / ABSORPTION DIGESTIVE / Adult / AGE / AGE DIFFERENCES / APOLIPOPROTEINS / APOPROTEINAS / APOPROTEINE / APOPROTEINS / ASH CONTENT / BIOCHEMICAL POLYMORPHISM / Biological and medical sciences / BODY COMPOSITION / Bone Density / Bone mineral density / BONES / Caffeine / CALCIO / CALCIUM / CHRONIC COURSE / chronic diseases / COLAGENO / COLLAGEN / COLLAGENE / COMPLEMENT ALIMENTAIRE / CONTENIDO DE CENIZA / CONTENIDO MINERAL / DENSIDAD / DENSITE / DENSITY / DIGESTIVE ABSORPTION / DISEASES / Diseases of the osteoarticular system / EDAD / ENVIRONMENTAL FACTORS / ESTROGENOS / ETHNIC GROUPS / ETHNICITY / EXPRESION GENICA / EXPRESSION DES GENES / FACTEUR DU MILIEU / FACTORES AMBIENTALES / Female / FENOTIPOS / GENE / GENE EXPRESSION / GENES / GENETIC FACTORS / GENETIC MARKERS / GENETICA / GENETICS / GENETIQUE / GENOTIPOS / GENOTYPE / GENOTYPES / GROUPE ETHNIQUE / GRUPOS ETNICOS / HUESOS / Humans / INGESTION DE NUTRIENTES / INGESTION DE SUBSTANCES NUTRITIVES / INTESTINAL ABSORPTION / LITERATURE REVIEWS / Male / MARCADORES GENETICOS / MARQUEUR GENETIQUE / Medical sciences / MINERAL CONTENT / nationalities and ethnic groups / NUTRIENT INTAKE / OESTROGENE / OESTROGENS / OSTEODISTROFIA / OSTEODYSTROPHIE / OSTEODYSTROPHY / Osteoporosis / Osteoporosis - genetics / Osteoporosis. Osteomalacia. Paget disease / PHENOTYPE / PHENOTYPES / POLIMORFISMO BIOQUIMICO / Polymorphism, Genetic / POLYMORPHISME BIOCHIMIQUE / PROCESO CRONICO / PROCESSUS CHRONIQUE / receptors / Receptors, Calcitriol - genetics / RIESGO / RISK / RISK FACTORS / RISQUE / SUPLEMENTOS / SUPPLEMENTS / TENEUR EN CENDRES / TENEUR EN ELEMENTS MINERAUX / VITAMIN D / vitamin supplements / VITAMINA D / VITAMINAS / VITAMINE / VITAMINE D / VITAMINS