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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

by Dyer, Roger A. , Waterland, Robert A. , Dominguez-Salas, Paula , Zeisel, Steven H. , Swan, Gary E. , Laritsky, Eleonora , Innis, Sheila M. , Moore, Sophie E. , Silver, Matt J. , Prentice, Andrew M. , Hennig, Branwen J. , Fulford, Anthony J. , Guan, Yongtao , Bergen, Andrew W. , Baker, Maria S. , Cox, Sharon E.

in 45/22 / 45/77 / 631/208/176/1988 / 692/308 / 692/53 / 692/700/2814 / 82/16 / 82/58 / Adult / Biomarkers - blood / Deoxyribonucleic acid / DNA / DNA Methylation - physiology / Epigenesis, Genetic - physiology / Female / Fertilization - physiology / Gambia / Hair Follicle - chemistry / Humanities and Social Sciences / Humans / Lymphocytes / Lymphocytes - chemistry / Maternal Nutritional Physiological Phenomena - physiology / multidisciplinary / Nutritional status / Offspring / Pregnancy / Science / Science (multidisciplinary) / Seasonal variations / Seasons

2014

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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

2014

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2014

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Journal Article

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

Dyer, Roger A.,

Waterland, Robert A.,

Dominguez-Salas, Paula,

Zeisel, Steven H.,

Swan, Gary E.,

Laritsky, Eleonora,

Innis, Sheila M.,

Moore, Sophie E.,

Silver, Matt J.,

Prentice, Andrew M.,

Hennig, Branwen J.,

Fulford, Anthony J.,

Guan, Yongtao,

Bergen, Andrew W.,

Baker, Maria S.,

Cox, Sharon E.

2014

Overview

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles. Maternal diet affects DNA methylation in the developing offspring, leading to phenotypic changes. Here, Dominguez-Salas et al . exploit seasonal variation in the diet of Gambian women to show that maternal methyl donor nutrient status around the time of conception predicts methylation levels at metastable epialleles in infants.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group

Subject

45/22

/ 45/77

/ 631/208/176/1988

/ 692/308

/ 692/53

/ 692/700/2814

/ 82/16