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Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment
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Journal Article
Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment
2021
Overview
Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes. It controls the expression of functional genes and is also involved in the regulation of numerous cellular processes. A large number of studies have demonstrated that HNF4α is involved in many human malignancies. Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis. In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin, nuclear factor-κB, signal transducer and activator of transcription 3, and transforming growth factor β signaling pathways); and highlight potential clinical uses of HNF4α as a biomarker and therapeutic target for cancer.
Cancer diagnosis: Possible protein biomarker
A regulatory protein that plays complex and varied roles in different cancers may provide a diagnostic biomarker and prove useful in future treatments. Hong Tang and co-workers at Sichuan University in Chengdu, China, reviewed current understanding of the functional role of the hepatocyte nuclear factor 4α (HNF4α) protein. Abnormal expression of HNF4α appears to be involved in cell proliferation, invasion and metastasis in some cancers, but may suppress tumor growth in other cancers. HNF4α has been found to influence signaling pathways involved in cancer induction and progression in early-stage liver and colorectal cancers. It may also help build resistance to chemotherapy in gastric cancer. The presence of abnormal HNF4α expression may provide a diagnostic and prognostic biomarker for certain cancers. Further investigations are needed, but drugs that target HNF4α could be valuable in combination cancer treatments.
Publisher
Nature Publishing Group UK,Springer Nature B.V,생화학분자생물학회
