Asset Details
Do you wish to reserve the book?
Structural basis for strand-transfer inhibitor binding to HIV intasomes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Structural basis for strand-transfer inhibitor binding to HIV intasomes
Do you wish to request the book?
Structural basis for strand-transfer inhibitor binding to HIV intasomes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Structural basis for strand-transfer inhibitor binding to HIV intasomes
2020
Overview
The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation of antiretroviral drugs, integrase strand-transfer inhibitors (INSTIs). Challenges associated with lentiviral intasome biochemistry have hindered high-resolution structural studies of how INSTIs bind to their native drug target. Here, we present high-resolution cryo–electron microscopy structures of HIV intasomes bound to the latest generation of INSTIs. These structures highlight how small changes in the integrase active site can have notable implications for drug binding and design and provide mechanistic insights into why a leading INSTI retains efficacy against a broad spectrum of drug-resistant variants. The data have implications for expanding effective treatments available for HIV-infected individuals.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Binding
/ DNA
/ Drugs
/ Genomes
/ Heterocyclic Compounds, 3-Ring
/ Heterocyclic Compounds, 4 or More Rings - chemistry
/ HIV
/ HIV Integrase Inhibitors - chemistry
/ Human immunodeficiency virus
/ Humans
/ Multiprotein Complexes - chemistry
/ Multiprotein Complexes - genetics
/ Mutation
/ Virus Integration - drug effects
/ Viruses
