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Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation

by Burgos da Silva, Marina , Castillo Flores, Nerea , Peled, Jonathan U , Sanchez-Escamilla, Míriam , Lin, Richard J , Gomes, Antonio L.C , Ponce, Doris M , Teshima, Takanori , Barker, Juliet N , Hashimoto, Daigo , Jenq, Robert R , Lew, Meagan V , Slingerland, John B , Wright, Roberta J , Weber, Daniela , Gessner, André , Politikos, Ioannis , Littmann, Eric R , Devlin, Sean M , Armijo, Gabriel K , Sung, Anthony D , Gyurkocza, Boglarka , van den Brink, Marcel R.M , Taur, Ying , Alarcon Tomas, Ana , Chao, Nelson J , Messina, Julia A , Giralt, Sergio A , Xavier, Joao B , Bohannon, Lauren , Perales, Miguel-Angel , Docampo, Melissa D , Amoretti, Luigi A , Cho, Christina , Romero, Kristi , Shono, Yusuke , Slingerland, Ann E , Scordo, Michael , Hayasaka, Kasumi , Brereton, Daniel G , Holler, Ernst , Yáñez San Segundo, Lucrecia , Shah, Gunjan L , Bush, Amy , Hasegawa, Yuta , Khan, Niloufer , Stein-Thoeringer, Christoph K , Clurman, Annelie G , Maloy, Molly , Pamer, Eric G , Fontana, Emily , Markey, Kate A

in Adult / Antibiotics / Biodiversity / Clinical outcomes / Death / Feces - microbiology / Female / Gastrointestinal Microbiome / Geographical variations / Graft-versus-host reaction / Hematopoietic Stem Cell Transplantation - mortality / Humans / Intestinal microflora / Intestine / Male / Microbiomes / Microbiota / Middle Aged / Mortality / Patients / Prognosis / Prospective Studies / rRNA 16S / Stem cell transplantation / Survival Analysis / Transplantation / Transplantation, Homologous - mortality

2020

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2020

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Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation

2020

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Journal Article

Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation

Burgos da Silva, Marina,

Castillo Flores, Nerea,

Peled, Jonathan U,

Sanchez-Escamilla, Míriam,

Lin, Richard J,

Gomes, Antonio L.C,

Ponce, Doris M,

Teshima, Takanori,

Barker, Juliet N,

Hashimoto, Daigo,

Jenq, Robert R,

Lew, Meagan V,

Slingerland, John B,

Wright, Roberta J,

Weber, Daniela,

Gessner, André,

Politikos, Ioannis,

Littmann, Eric R,

Devlin, Sean M,

Armijo, Gabriel K,

Sung, Anthony D,

Gyurkocza, Boglarka,

van den Brink, Marcel R.M,

Taur, Ying,

Alarcon Tomas, Ana,

Chao, Nelson J,

Messina, Julia A,

Giralt, Sergio A,

Xavier, Joao B,

Bohannon, Lauren,

Perales, Miguel-Angel,

Docampo, Melissa D,

Amoretti, Luigi A,

Cho, Christina,

Romero, Kristi,

Shono, Yusuke,

Slingerland, Ann E,

Scordo, Michael,

Hayasaka, Kasumi,

Brereton, Daniel G,

Holler, Ernst,

Yáñez San Segundo, Lucrecia,

Shah, Gunjan L,

Bush, Amy,

Hasegawa, Yuta,

Khan, Niloufer,

Stein-Thoeringer, Christoph K,

Clurman, Annelie G,

Maloy, Molly,

Pamer, Eric G,

Fontana, Emily,

Markey, Kate A

2020

Overview

In this study, the gastrointestinal microbiome was serially monitored in patients undergoing allogeneic hematopoietic-cell transplantation at four centers. Lower microbial diversity was associated with poorer outcomes after HCT.

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Publisher

Massachusetts Medical Society

Subject

/ Death

/ Feces - microbiology

/ Female