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Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice
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Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice
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Journal Article
Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice
2020
Overview
Societal lifestyle changes, especially increased consumption of a high-fat diet lacking dietary fibers, lead to gut microbiota dysbiosis and enhance the incidence of adiposity and chronic inflammatory disease. We aimed to investigate the metabolic effects of inulin with different degrees of polymerization on high-fat diet-fed C57BL/6 J mice and to evaluate whether different health outcomes are related to regulation of the gut microbiota. Short-chain and long-chain inulins exert beneficial effects through alleviating endotoxemia and inflammation. Antiinflammation was associated with a proportional increase in short-chain fatty acid-producing bacteria and an increase in the concentration of short-chain fatty acids. Inulin might decrease endotoxemia by increasing the proportion of
Bifidobacterium
and
Lactobacillus
, and their inhibition of endotoxin secretion may also contribute to antiinflammation. Interestingly, the beneficial health effects of long-chain inulin were more pronounced than those of short-chain inulin. Long-chain inulin was more dependent than short-chain inulin on species capable of processing complex polysaccharides, such as
Bacteroides
. A good understanding of inulin-gut microbiota-host interactions helps to provide a dietary strategy that could target and prevent high-fat diet-induced endotoxemia and inflammation through a prebiotic effect.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/77
/ 64/60
/ Animals
/ Bifidobacterium - drug effects
/ Diet
/ Diet, High-Fat - adverse effects
/ Endotoxemia - prevention & control
/ Fibers
/ Gastrointestinal Microbiome - drug effects
/ Humanities and Social Sciences
/ Inflammation - prevention & control
/ Inulin
/ Lactobacillus - drug effects
/ Male
/ Mice
/ Protective Agents - pharmacology
/ Protective Agents - therapeutic use
/ Science
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