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Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis
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Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis
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Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis
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Journal Article
Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis
2019
Overview
The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1
+
CD45
+
progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 mice, Sca-1
+
CD45
+
cells were localised to adventitia and lacked surface expression of endothelial markers (<1% for CD31, CD144, TIE-2). In contrast, they did show expression of CD31, CD144, TIE-2 and VEGFR2 in atherosclerotic
ApoE
−/−
aortas. Although Sca-1
+
CD45
+
cells from C57BL/6 aorta did not express CD31, they formed CD31
+
colonies in endothelial differentiation media and produced interconnecting vascular-like cords in Matrigel that contained both endothelial cells and a small population of macrophages, which were located at branch points. Transfer of aortic Sca-1
+
CD45
+
cells generated endothelial cells and neovessels
de novo
in a hindlimb model of ischaemia and resulted in a 50% increase in perfusion compared to cell-free control. Similarly, their injection into the carotid adventitia of
ApoE
−/−
mice produced donor-derived adventitial and peri-adventitial microvessels after atherogenic diet, suggestive of newly formed vasa vasorum. These findings show that beyond its content of macrophage progenitors, adventitial Sca-1
+
CD45
+
cells are also vasculogenic and may be a source of
vasa vasorum
during atherogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/100
/ 13/106
/ 13/31
/ 13/51
/ 38/61
/ 38/77
/ 64/60
/ Animals
/ Aorta
/ Endothelial Cells - physiology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Ischemia
/ Leukocyte Common Antigens - metabolism
/ Male
/ Membrane Proteins - metabolism
/ Mice
/ Neovascularization, Pathologic - etiology
/ Neovascularization, Pathologic - pathology
/ Science
