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Identification of pentadecapeptide mimicking muramyl peptide
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Identification of pentadecapeptide mimicking muramyl peptide
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Journal Article
Identification of pentadecapeptide mimicking muramyl peptide
2007
Overview
We used monoclonal antibody, generated against
N-acetylglucosaminyl-β1-4-
N-acetylmuramyl-alanyl-
d-isoglutamine (GMDP), and phage display libraries of random peptides to select for oligopeptides, that mimic GMDP in their biological activity. Selected phage clones displayed a peptide RVPPRYHAKISPMVN (called RN-peptide) on their surface. This peptide was synthesized. RN-peptide was shown to augment the antibody response to ovalbumin in mice while the peptide was non-immunogenic and non-pyrogenic. We also characterized adjuvant activity of 14-, 10- and 7-mer analogs of RN-peptide truncated at the C-terminus and found them to be active. Because both carbohydrate and peptide fragments are critical for the biological activity of muramyl peptides, the results indicate that RN-peptide mimicks the spatial structure of intact GMDP.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives
/ Acetylmuramyl-Alanyl-Isoglutamine - chemistry
/ Acetylmuramyl-Alanyl-Isoglutamine - immunology
/ Acetylmuramyl-Alanyl-Isoglutamine - metabolism
/ Adjuvant
/ Animals
/ Antibodies, Monoclonal - immunology
/ DNA
/ E coli
/ Female
/ Histocompatibility Antigens Class II - biosynthesis
/ Histocompatibility Antigens Class II - immunology
/ Lectins
/ Ligands
/ Mice
/ Peptides
/ Rats
