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Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer

by Turner, Nicholas C. , Grinsted, Lynda , Tokunaga, Eriko , Park, Yeon Hee , Toi, Masakazu , Oliveira, Mafalda , Yousef, Samih , Rugo, Hope S. , Krivorotko, Petr , Loibl, Sibylle , Okera, Meena , de Bruin, Elza C. , Morales Murillo, Serafin , Zhukova, Lyudmila , Gomez Moreno, Henry L. , Jhaveri, Komal , Dalenc, Florence , Cortes, Javier , Foxley, Andrew , Hu, Xichun , Howell, Sacha J. , Sohn, Joohyuk , Schiavon, Gaia

in Adverse events / AKT protein / AKT1 protein / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Aromatase / Aromatase Inhibitors - adverse effects / Aromatase Inhibitors - therapeutic use / Breast Cancer / Breast Neoplasms - drug therapy / Breast Neoplasms - pathology / Cancer therapies / Cyclin-dependent kinase 4 / Cyclin-dependent kinases / Diarrhea / Disease prevention / Double-Blind Method / Double-blind studies / Endocrine therapy / Estrogens / Female / Fulvestrant / Fulvestrant - adverse effects / Fulvestrant - therapeutic use / Hematology / Humans / Kinases / Magnetic resonance imaging / Male / Metastasis / Mutation / Neoplasm Recurrence, Local - drug therapy / Oncology / Placebos / Post-menopause / Proto-Oncogene Proteins c-akt / PTEN protein / Quality of life / Receptor, ErbB-2 / Regulatory approval / Survival / Treatments in Oncology / Tumors / Womens health

2023

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Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer

2023

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2023

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Journal Article

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer

Turner, Nicholas C.,

Grinsted, Lynda,

Tokunaga, Eriko,

Park, Yeon Hee,

Toi, Masakazu,

Oliveira, Mafalda,

Yousef, Samih,

Rugo, Hope S.,

Krivorotko, Petr,

Loibl, Sibylle,

Okera, Meena,

de Bruin, Elza C.,

Morales Murillo, Serafin,

Zhukova, Lyudmila,

Gomez Moreno, Henry L.,

Jhaveri, Komal,

Dalenc, Florence,

Cortes, Javier,

Foxley, Andrew,

Hu, Xichun,

Howell, Sacha J.,

Sohn, Joohyuk,

Schiavon, Gaia

2023

Overview

Among persons with breast cancer previously treated with hormonal therapy, the AKT pathway inhibitor capivasertib when added to fulvestrant significantly prolonged progression-free survival as compared with fulvestrant alone.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ AKT protein

/ AKT1 protein

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Aromatase

/ Aromatase Inhibitors - adverse effects