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Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
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Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
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Journal Article
Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
2017
Overview
The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through β1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.
The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/109
/ 13/51
/ 13/95
/ 14/19
/ 14/35
/ 14/63
/ 38/1
/ 9/74
/ Animals
/ Dentate Gyrus - growth & development
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Mice
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ Neural Stem Cells - cytology
/ Neural Stem Cells - metabolism
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ Science
/ Spine
