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Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis
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Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis
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Journal Article
Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis
2022
Overview
Obesity is a global pandemic that is causally linked to many life-threatening diseases. Apart from some rare genetic conditions, the biological drivers of overeating and reduced activity are unclear. Here, we show that neurotensin-expressing neurons in the mouse interstitial nucleus of the posterior limb of the anterior commissure (IPAC), a nucleus of the central extended amygdala, encode dietary preference for unhealthy energy-dense foods. Optogenetic activation of IPAC
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neurons promotes obesogenic behaviors, such as hedonic eating, and modulates food preference. Conversely, acute inhibition of IPAC
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neurons reduces feeding and decreases hedonic eating. Chronic inactivation of IPAC
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neurons recapitulates these effects, reduces preference for sweet, non-caloric tastants and, furthermore, enhances locomotion and energy expenditure; as a result, mice display long-term weight loss and improved metabolic health and are protected from obesity. Thus, the activity of a single neuronal population bidirectionally regulates energy homeostasis. Our findings could lead to new therapeutic strategies to prevent and treat obesity.
Furlan et al. report that neurotensin-expressing neurons in the IPAC encode preference for unhealthy energy-dense foods and drive hedonic eating. Thus, inhibition of these neurons reduces hedonic eating, improves metabolic health and prevents obesity.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
