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Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018
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Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018
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Journal Article
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018
2020
Overview
Staphylococcus aureus
or methicillin-resistant
Staphylococcus aureus
(MRSA) is an important issue associated with significant morbidity and mortality and well known as a predominant pathogen causing bloodstream infection (BSIs) globally. To estimate the antibiotic resistance and molecular characteristics of
S. aureus
causing BSIs in Shanghai, 120
S. aureus
isolates (20 isolates each year) from the patients with
S. aureus
BSIs from 2013 to 2018 were randomly selected and enrolled in this study. Fifty-three (44.2%) MRSA isolates were determined, and no isolate was found resistant to vancomycin, daptomycin, synercid, linezolid and ceftaroline. The toxin genes
tst
,
sec
,
seg
and
sei
were found more frequently among MRSA isolates compared with MSSA isolates (all
P
< 0.0001). Twenty-nine sequence types (STs) were identified, and ST5 (23.3%) was the most common ST, followed by ST398 (11.7%) and ST764 (10.0%). SCC
mec
II (73.6%) was the most frequent SCC
mec
type among MRSA isolates. The dominant clonal complexes (CCs) were CC5 (ST5, ST764, ST965 and ST3066; 36.7%) and the livestock-associated clone CC398 (ST398, 11.7%). MRSA-CC5 was the predominant CC among MRSA isolates (37/53, 69.8%), and CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates. In addition, all 29
tst
-positive MRSA isolates were CC5-MRSA as well. Our study provided the properties and genotypes of
S. aureus
causing BSIs at Ruijin Hospital in Shanghai from 2013 to 2018, and might suggest of value clues for the further study insights into pathogenic mechanisms intrinsically referring to the development of human-adapted
S. aureus
clones and their diffusions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/77
/ Adult
/ Aged
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Child
/ Female
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Male
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - isolation & purification
/ Science
/ Staphylococcal enterotoxin G
/ Staphylococcal Infections - drug therapy
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - isolation & purification
/ Toxins
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