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Alterations in resting‐state functional connectivity in pediatric patients with tuberous sclerosis complex
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Alterations in resting‐state functional connectivity in pediatric patients with tuberous sclerosis complex
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Alterations in resting‐state functional connectivity in pediatric patients with tuberous sclerosis complex
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Journal Article
Alterations in resting‐state functional connectivity in pediatric patients with tuberous sclerosis complex
2021
Overview
Objective
To investigate resting‐state functional connectivity (FC) in pediatric patients with tuberous sclerosis complex and intractable epilepsy requiring surgery.
Methods
Resting‐state functional MRI was utilized to investigate functional connectivity in 13 pediatric patients with tuberous sclerosis complex (TSC) and intractable epilepsy requiring surgery.
Results
The majority of patients demonstrated a resting‐state network architecture similar to those reported in healthy individuals. However, preoperative differences were evident between patients with high versus low tuber burden, as well as those with good versus poor neurodevelopmental outcomes, most notably in the cingulo‐opercular and visual resting‐state networks. One patient with high tuber burden and poor preoperative development and seizure control had nearly normal development and seizure resolution after surgery. This was accompanied by significant improvement in resting‐state network architecture just one day postoperatively.
Significance
Although many patients with tuberous sclerosis complex and medically refractory epilepsy demonstrate functional connectivity patterns similar to healthy children, relationships within and between RSNs demonstrate clear differences in patients with higher tuber burden and worse outcomes. Improvements in resting‐state network organization postoperatively may be related to epilepsy surgery outcomes, providing candidate biomarkers for clinical management in this high‐risk population.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
