Asset Details
Do you wish to reserve the book?
Epigenome‐wide analyses identify DNA methylation signatures of dementia risk
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epigenome‐wide analyses identify DNA methylation signatures of dementia risk
Do you wish to request the book?
Epigenome‐wide analyses identify DNA methylation signatures of dementia risk
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epigenome‐wide analyses identify DNA methylation signatures of dementia risk
2020
Overview
Introduction Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer's disease (AD)–free participants. Methods Associations between dementia risk measures (family history, AD genetic risk score [GRS], and dementia risk scores [combining lifestyle, demographic, and genetic factors]) and whole‐blood DNA methylation were assessed in discovery and replication samples (n = ~400 to ~5000) from Generation Scotland. Results AD genetic risk and two dementia risk scores were associated with differential methylation. The GRS associated predominantly with methylation differences in cis but also identified a genomic region implicated in Parkinson disease. Loci associated with dementia risk scores were enriched for those previously associated with body mass index and alcohol consumption. Discussion Dementia risk measures show widespread association with blood‐based methylation, generating several hypotheses for assessment by future studies.
