Asset Details
Do you wish to reserve the book?
Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
Do you wish to request the book?
Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
2021
Overview
In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistical models were used to investigate the associations between age groups, clinical characteristics and treatment outcomes. Compared to younger patients, older patients were more likely to present with advanced-stage disease (20.6% vs. 15.1%,
p
= .028). However, among those with non-metastatic disease, younger patients tended to have more aggressive pathological features, including positive axillary lymph nodes (73.2% vs. 55.6%,
p
< .001), T-3/4 (28.2% vs. 13.8%,
p
< .001) and HER2-positive disease (29.3% vs. 16.3%,
p
< .001). The 5-year overall survival (OS) rate was significantly better for the younger (72.1%) compared to the older (67.6%),
p
= .035. However, no significant difference was observed in disease-free survival (DFS) between the two groups.In conclusion, younger patients with breast cancer present with worse clinical and pathological features, albeit a better OS rate. The difference in DFS between the two groups was not insignificant, suggesting that older women were more likely to die from non-cancer related causes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
