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Experimental Evidence Supports a Sex-Specific Selective Sieve in Mitochondrial Genome Evolution
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Experimental Evidence Supports a Sex-Specific Selective Sieve in Mitochondrial Genome Evolution
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Journal Article
Experimental Evidence Supports a Sex-Specific Selective Sieve in Mitochondrial Genome Evolution
2011
Overview
Mitochondria are maternally transmitted; hence, their genome can only make a direct and adaptive response to selection through females, whereas males represent an evolutionary dead end. In theory, this creates a sex-specific selective sieve, enabling deleterious mutations to accumulate in mitochondrial genomes if they exert male-specific effects. We tested this hypothesis, expressing five mitochondrial variants alongside a standard nuclear genome in Drosophila melanogaster, and found striking sexual asymmetry in patterns of nuclear gene expression. Mitochondrial polymorphism had few effects on nuclear gene expression in females but major effects in males, modifying nearly 10% of transcripts. These were mostly male-biased in expression, with enrichment hotspots in the testes and accessory glands. Our results suggest an evolutionary mechanism that results in mitochondrial genomes harboring male-specific mutation loads.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biologi
/ Biological and medical sciences
/ Biology
/ Classical genetics, quantitative genetics, hybrids
/ DNA, Mitochondrial - genetics
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Female
/ Females
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Male
/ Males
/ Mutation
/ Oligonucleotide Array Sequence Analysis
/ Ovaries
/ testes
