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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron
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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron
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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron
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Journal Article
Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron
2023
Overview
SARS-CoV-2-BA.4/5-adapted-bivalent-BNT162b2-vaccine (
bv
BNT), developed in response to the recent emergence of immune-evasive Omicron-variants, has been given to individuals who completed at least 2-doses of the monovalent-BNT162b2-vaccine (
mv
BNT). In the present cohort study, we evaluated neutralization-titers (NT
50
s) against Wuhan-strain (SCoV2
Wuhan
) and Omicron-sublineages including BA.2/BA.5/BQ.1.1/XBB/XBB.1.5, and vaccine-elicited S1-binding-IgG in sera from participants-vaccinated with 5th-
bv
BNT following 4th-
mv
BNT. The 5th-
bv
BNT-dose elicited good protective-activity against SCoV2
Wuhan
with geometric-mean (gMean)-NT
50
of 1966–2091, higher than the peak-values post-4th-
mv
BNT with no statistical significance, and favorable neutralization-activity against not only BA.5 but also BA.2, with ~ 3.2-/~ 2.2-fold greater gMean-NT
50
compared to the peak-values post-4th-
mv
BNT-dose, in participants with or without risk factors. However, neutralization-activity of sera post-5th-
bv
BNT-dose was low against BQ.1.1/XBB/XBB.1.5. Interestingly, participants receiving
bv
BNT following breakthrough (BT) infection during Omicron-wave had significantly enhanced neutralization-activity against SCoV2
Wuhan
/BA.2/BA.5 with ~ 4.6-/~ 6.3-/~ 8.1-fold greater gMean-NT
50
, respectively, compared to uninfected participants receiving
bv
BNT. Sera from BT-infected-participants receiving
bv
BNT had enhanced neutralization-activity against BQ.1.1/XBB/XBB.1.5 by ~ 3.8-fold compared to those from the same participants post-4th-
mv
BNT-dose, and had enhanced gMean-NT
50
~ 5.4-fold greater compared to those of uninfected-participants’ sera post-
bv
BNT. These results suggest that repeated stimulation brought about by exposure to BA.5’s-Spike elicit favorable cross-neutralization-activity against various SARS-CoV-2-variants.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
