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Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

by Fang, Vicky J. , Ip, Dennis K. M. , Chiu, Susan S. , Chan, Kwok-Hung , Leung, Gabriel M. , Peiris, J. S. Malik , Nishiura, Hiroshi , Cowling, Benjamin J. , Ng, Sophia

in Adolescent / Biological and medical sciences / BRIEF REPORTS / Child / Children & youth / Diseases / Female / Human viral diseases / Humans / Immunity / Immunosuppression / Incidence / Infections / Infectious diseases / Influenza / Influenza vaccines / Influenza Vaccines - administration & dosage / Influenza Vaccines - adverse effects / Innate immunity / Male / Medical sciences / Orthomyxoviridae / Pandemics / Placebos / Placebos - administration & dosage / Respiratory Tract Infections - epidemiology / Respiratory Tract Infections - immunology / Risk Assessment / Vaccination / Vaccines / Vaccines, Inactivated - administration & dosage / Vaccines, Inactivated - adverse effects / Viral diseases / Viral diseases of the respiratory system and ent viral diseases / Virus Diseases - epidemiology / Virus Diseases - immunology / Viruses

2012

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Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

by Fang, Vicky J. , Ip, Dennis K. M. , Chiu, Susan S. , Chan, Kwok-Hung , Leung, Gabriel M. , Peiris, J. S. Malik , Nishiura, Hiroshi , Cowling, Benjamin J. , Ng, Sophia

2012

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Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

by Fang, Vicky J. , Ip, Dennis K. M. , Chiu, Susan S. , Chan, Kwok-Hung , Leung, Gabriel M. , Peiris, J. S. Malik , Nishiura, Hiroshi , Cowling, Benjamin J. , Ng, Sophia

2012

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Journal Article

Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

Fang, Vicky J.,

Ip, Dennis K. M.,

Chiu, Susan S.,

Chan, Kwok-Hung,

Leung, Gabriel M.,

Peiris, J. S. Malik,

Nishiura, Hiroshi,

Cowling, Benjamin J.,

Ng, Sophia

2012

Overview

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

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Publisher

Oxford University Press

Subject

Adolescent

/ Biological and medical sciences

/ BRIEF REPORTS

/ Child

/ Children & youth

/ Diseases

/ Female