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Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood
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Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood
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Journal Article
Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood
2019
Overview
Previous research in rodents and humans points to an evolutionarily conserved profile of blunted threat extinction learning during adolescence, underpinned by brain structures such as the amygdala and medial prefrontal cortex (mPFC). In this study, we examine age-related effects on the function and structural connectivity of this system in threat extinction learning in adolescence and young adulthood. Younger age was associated with greater amygdala activity and later engagement of the mPFC to learned threat cues as compared to safety cues. Furthermore, greater structural integrity of the uncinate fasciculus, a white matter tract that connects the amygdala and mPFC, mediated the relationship between age and mPFC engagement during extinction learning. These findings suggest that age-related changes in the structure and function of amygdala-mPFC circuitry may underlie the protracted maturation of threat regulatory processes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 59/57
/ Adult
/ Age
/ Amygdala
/ Child
/ Cues
/ Extinction, Psychological - physiology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Image Processing, Computer-Assisted - methods
/ Learning
/ Male
/ Neural Pathways - physiopathology
/ Prefrontal Cortex - physiopathology
/ Science
