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Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
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Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
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Journal Article
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
2018
Overview
Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuroprotective effects
in vitro
in human cell culture models and is sufficient to improve cognition
in vivo
in aged mice. Furthermore, in a human cohort, using mitochondrial GWAS, we identified a specific SNP (rs2854128) in the humanin-coding region of the mitochondrial genome that is associated with a decrease in circulating humanin levels. In a large, independent cohort, consisting of a nationally-representative sample of older adults, we find that this SNP is associated with accelerated cognitive aging, supporting the concept that humanin is an important factor in cognitive aging.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45
/ 45/23
/ 45/43
/ 64/60
/ Age
/ Aging
/ Animals
/ Cognitive Dysfunction - genetics
/ Female
/ Genetics
/ Genome, Mitochondrial - genetics
/ Genomes
/ Humanin
/ Humanities and Social Sciences
/ Humans
/ Intracellular Signaling Peptides and Proteins - genetics
/ Male
/ Mice
/ Neurodegenerative Diseases - genetics
/ Neuroprotective Agents - metabolism
/ Peptides
/ Polymorphism, Single Nucleotide - genetics
/ Science
