Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer‐hybrid epitope long peptide of MAGE‐A4 cancer antigen

by Ohtake, Junya , Homma, Shigenori , Kitamura, Hidemitsu , Takahashi, Norihiko , Togashi, Yuji , Ohkuri, Takayuki , Todo, Satoru , Wakita, Daiko , Nishimura, Takashi

in Amino acids / Antigens / Antigens, Neoplasm - immunology / Cancer vaccines / Cancer Vaccines - therapeutic use / Carcinoembryonic antigen / Case Report / Clinical trials / Colon cancer / Colonic Neoplasms - immunology / Colonic Neoplasms - pathology / Colonic Neoplasms - therapy / Colorectal cancer / Enzymes / Epitopes / Epitopes - immunology / Hepatitis / Human papillomavirus / Humans / Immune response (humoral) / Immunoglobulin G / Immunotherapy, Active / Leukocytes / Lung cancer / Lung Neoplasms - immunology / Lung Neoplasms - pathology / Lung Neoplasms - therapy / Lymphocytes / Lymphocytes T / Male / Metastases / Metastasis / Middle Aged / Neoplasm Proteins - immunology / Patients / Peptides / Prognosis / Th1 Cells - immunology / Tumor markers / Tumors

2012

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer‐hybrid epitope long peptide of MAGE‐A4 cancer antigen

by Ohtake, Junya , Homma, Shigenori , Kitamura, Hidemitsu , Takahashi, Norihiko , Togashi, Yuji , Ohkuri, Takayuki , Todo, Satoru , Wakita, Daiko , Nishimura, Takashi

2012

Confirm

Do you wish to request the book?

First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer‐hybrid epitope long peptide of MAGE‐A4 cancer antigen

by Ohtake, Junya , Homma, Shigenori , Kitamura, Hidemitsu , Takahashi, Norihiko , Togashi, Yuji , Ohkuri, Takayuki , Todo, Satoru , Wakita, Daiko , Nishimura, Takashi

2012

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer‐hybrid epitope long peptide of MAGE‐A4 cancer antigen

Ohtake, Junya,

Homma, Shigenori,

Kitamura, Hidemitsu,

Takahashi, Norihiko,

Togashi, Yuji,

Ohkuri, Takayuki,

Todo, Satoru,

Wakita, Daiko,

Nishimura, Takashi

2012

Overview

A patient with pulmonary metastasis of colon cancer was treated with artificially synthesized helper/killer‐hybrid epitope long peptide (H/K‐HELP) of MAGE‐A4 cancer antigen. The patient was vaccinated with MAGE‐A4‐H/K‐HELP combined with OK432 and Montanide ISA‐51. There were no severe side‐effects except for a skin reaction at the injection site. MAGE‐A4‐H/K‐HELP induced MAGE‐A4‐specific Th1 and Tc1 immune responses and the production of MAGE‐A4‐specific complement‐fixing IgG antibodies. Tumor growth and carcinoembryonic antigen tumor marker were significantly decreased in the final diagnosis. This is the first report that artificially synthesized MAGE‐A4‐H/K‐HELP induces Th1‐dependent cellular and humoral immune responses in a human cancer patient. (Cancer Sci 2012; 103: 150–153)

Share this book

Add to My Shelf

Publisher

Blackwell Publishing Ltd,John Wiley & Sons, Inc

Subject

Amino acids

/ Antigens

/ Antigens, Neoplasm - immunology

/ Cancer vaccines

/ Cancer Vaccines - therapeutic use

/ Carcinoembryonic antigen

/ Case Report