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Non-apical mitoses contribute to cell delamination during mouse gastrulation
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Non-apical mitoses contribute to cell delamination during mouse gastrulation
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Journal Article
Non-apical mitoses contribute to cell delamination during mouse gastrulation
2024
Overview
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole. These observations suggest that non-apical mitoses might play a role in cell delamination. We aim to uncover and challenge the molecular determinants of mitosis position in different regions of the epiblast through computational modeling and pharmacological treatments of embryos and stem cell-based epiblast spheroids. Blocking basement membrane degradation at the streak has no impact on the asymmetry in mitosis frequency and position. By contrast, disturbance of the actomyosin cytoskeleton or cell cycle dynamics elicits ectopic non-apical mitosis and shows that the streak region is characterized by local relaxation of the actomyosin cytoskeleton and less stringent regulation of cell division. These factors are essential for normal dynamics at the streak and favor cell delamination from the epiblast.
During mouse gastrulation the primitive streak is an area of cell division and epithelial-to-mesenchymal transition, though how mitoses and cell delamination are linked is not clear. Here they show that a faster cell cycle and relaxation of the actomyosin cytoskeleton result in the occurrence of non-apical mitosis, which favors cell delamination.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
