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Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

by Poole, Jeanne , Hammes, Stephen , Brown, Mary W. , Daubert, James , Zareba, Wojciech , Moss, Arthur J. , Klein, Helmut , Beck, Christopher , Solomon, Scott , Schuger, Claudio , Wilber, David , Estes, Mark , Greenberg, Henry , Knops, Reinoud , Cannom, David , Goldenberg, Ilan , Kosiborod, Mikhail , Huang, David , Kutyifa, Valentina , Singh, Jagmeet P.

in Age / Aged / Cardiology / Cardiovascular / Cardiovascular disease / Clinical trials / Collaboration / Death, Sudden, Cardiac - epidemiology / Death, Sudden, Cardiac - etiology / Death, Sudden, Cardiac - prevention & control / Defibrillators / Defibrillators, Implantable / Diabetes / Diabetes mellitus / Failure analysis / Female / Follow-Up Studies / Health risk assessment / Heart / Heart attacks / Heart diseases / Heart failure / Humans / Implantation / Incidence / Infections / Male / Medical diagnosis / Mortality / Myocardial infarction / Myocardial Infarction - complications / Patients / Prospective Studies / Survival Rate - trends / Task forces / Transplants & implants / Treatment Outcome / United States - epidemiology / Ventricle

2017

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Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

2017

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Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

2017

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Journal Article

Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

Poole, Jeanne,

Hammes, Stephen,

Brown, Mary W.,

Daubert, James,

Zareba, Wojciech,

Moss, Arthur J.,

Klein, Helmut,

Beck, Christopher,

Solomon, Scott,

Schuger, Claudio,

Wilber, David,

Estes, Mark,

Greenberg, Henry,

Knops, Reinoud,

Cannom, David,

Goldenberg, Ilan,

Kosiborod, Mikhail,

Huang, David,

Kutyifa, Valentina,

Singh, Jagmeet P.

2017

Overview

Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post–myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator.

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Publisher

Elsevier Inc,Elsevier Limited

Subject

Age

/ Aged

/ Cardiology

/ Cardiovascular

/ Cardiovascular disease

/ Clinical trials

/ Collaboration