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Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact
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Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact
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Journal Article
Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact
2019
Overview
p16 and p53 are frequently altered intracellular pathways in cancers. We investigated the aberrant expression of p16 and its relationship with p53 and HPV status in primary non-small-cell lung carcinoma.
Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV
hybridization were analyzed.
p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamous cell carcinoma (n = 88). HPV was detected in 16 and 10.2% of ADC and squamous cell carcinoma. In ADCs, p16 positive tumors demonstrated a favorable median overall survival time of 60.9 months, compared with p16 negative tumors of 46.9 months (p < 0.05). Furthermore, we did not find significant relationships between p16 expression and HPV status, nor with p53 expression.
p16 play an unique role in lung cancer survival. The mechanism of p16 needs to be further studied.
Publisher
Future Medicine Ltd
Subject
/ Adenocarcinoma of Lung - metabolism
/ Adenocarcinoma of Lung - pathology
/ Adenocarcinoma of Lung - virology
/ Adult
/ Aged
/ Antigens
/ Biomarkers, Tumor - metabolism
/ Carcinoma, Non-Small-Cell Lung - metabolism
/ Carcinoma, Non-Small-Cell Lung - pathology
/ Carcinoma, Non-Small-Cell Lung - virology
/ Carcinoma, Squamous Cell - metabolism
/ Carcinoma, Squamous Cell - pathology
/ Carcinoma, Squamous Cell - virology
/ Cyclin-Dependent Kinase Inhibitor p16 - metabolism
/ Female
/ Genomes
/ HPV
/ Humans
/ Male
/ Mutation
/ Non-small cell lung carcinoma
/ p16
/ p53
/ Papillomaviridae - isolation & purification
/ Studies
/ Tumor Suppressor Protein p53 - metabolism
/ Tumors
/ Vaccines
