Asset Details
Do you wish to reserve the book?
Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients
Do you wish to request the book?
Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients
2018
Overview
Tumor regression grade of the primary tumor (TRG‐PT) and residual lymph node metastasis have been pathologically determined in esophageal squamous cell carcinoma (ESCC) patients who had received neoadjuvant chemotherapy (nCT) followed by surgery; however, TRG of the metastatic tumor involving lymph nodes (LN) has not yet been determined. The aim of the present study was to clarify the impact of TRG on the prognosis of ESCC patients. ESCC patients (n = 110) who had received nCT followed by surgery were enrolled. Dissected LN were classified into 2 categories: plausible positive metastatic LN (pp‐MLN) where viable and/or degenerated ESCC cells and/or tissue modifications were observed, and non‐metastatic LN (non‐MLN) where neither of them was observed. We defined nCT‐effective rate (CER) as the ratio of the number of pp‐MLN that showed tumor regression to the total number of pp‐MLN, and divided CER into low‐CER (LCER; ≥0% and <50%) and high‐CER (HCER; ≥50% and ≤100%). Relationships between CER and clinicopathological factors including prognosis were then examined. Multivariate analyses of 110 patients indicated that ypT3‐4 (P = .023, HR; 2.551), positive venous infiltration (P = .006, HR; 3.526), and LCER (P = .033, HR; 1.922) were independently associated with shorter recurrence‐free survival (RFS). Multivariate analyses of 43 patients with grade 0 TRG‐PT showed that ypT3‐4 (P = .033, HR; 3.397) and LCER (P = .008, HR; 3.543) were independently associated with shorter RFS. This study showed that CER was one of the prognostic factors for ESCC patients who had received nCT followed by surgery. Tumor regression grade in lymph nodes was associated with the prognoses of esophageal squamous cell carcinoma (ESCC) patients after neoadjuvant chemotherapy (nCT). This important study shows a new predictor for ESCC patients after nCT.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Aged
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Biopsy
/ Carcinoma, Squamous Cell - drug therapy
/ Carcinoma, Squamous Cell - pathology
/ Carcinoma, Squamous Cell - surgery
/ Esophageal Neoplasms - drug therapy
/ Esophageal Neoplasms - pathology
/ Esophageal Neoplasms - surgery
/ esophageal squamous cell carcinoma
/ Female
/ Humans
/ Male
/ Original
/ Patients
/ Surgery
/ tumor regression grade of lymph node
/ tumor regression grade of primary tumor
/ Tumors
