Journal Article

Single-incision versus conventional multiport laparoscopic surgery for colorectal cancer: a meta-analysis of randomized controlled trials and propensity-score matched studies

Wei, Mingtian, Wu, Qingbin, Zhang, Xubing, Wang, Ziqiang, Gu, Chaoyang

2021

Overview

Purpose To compare single-incision laparoscopic surgery (SILS) and multiport laparoscopic surgery (MLS) for colorectal cancer in terms of short- and long-term outcomes. Methods A systematic literature search was performed in PubMed, Web of Science, and Embase. Randomized controlled trials (RCTs) and propensity-score matched (PSM) studies comparing SILS and MLS for colorectal cancer were enrolled. Outcomes of interests included intraoperative, postoperative, pathological, and survival outcomes. Results Sixteen studies (6 RCTs and 10 PSM studies) published between 2012 and 2020 with a total of 2425 patients were enrolled. Compared with MLS, SILS was associated with less postoperative pain at postoperative day (POD) 1 ( P = 0.02, MWD = −0.73, 95%CI: −1.37, −0.09) and POD2 ( P < 0.001, MWD= −1.10, 95%CI: −1.45, −0.74) and shorter length of total incision length ( P < 0.001, MWD = −3.31, 95%CI: −3.95, −2.67). No differences were observed in terms of operative time, blood loss, intraoperative and postoperative complications, incision hernia, and pathological or survival outcomes between SILS and MLS. Subgroup analysis for right-sided colon cancer, sigmoid colon cancer, and rectosigmoid colon cancer showed that the SILS group was only associated with less postoperative pain and shorter total incision length. The surgical and pathological outcomes were comparable between SILS and MLS. Conclusions SILS is a beneficial alternative to MLS in select colorectal cancer patients, especially for right-sided colon cancer, sigmoid colon cancer, and rectosigmoid cancer, with better cosmetic effects and less postoperative pain. Simultaneously, SILS does not compromise intraoperative and postoperative complications, surgical quality, or long-term outcomes.

• Publisher: Springer Berlin Heidelberg,Springer,Springer Nature B.V
• Subject: Abdominal surgery / Body mass index / Cancer / Clinical trials / Colectomy / Collaboration / Colon cancer / Colorectal cancer / Comparative analysis / Complications / Gastroenterology / Hepatology / Hernia / Hernias / Humans / Internal Medicine / Laparoscopic surgery / Laparoscopy / Length of Stay / Medicine / Medicine & Public Health / Meta-analysis / Oncology, Experimental / Operative Time / Pain / Patients / Postoperative / Proctology / Randomized Controlled Trials as Topic / Review / Sigmoid Neoplasms - surgery / Surgery / Survival / Treatment Outcome