Asset Details
Do you wish to reserve the book?
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
Do you wish to request the book?
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
2018
Overview
Background
Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes. The aim of this study was to determine the effect of selected genetic polymorphisms in Uncoupling protein 1 (
UCP1
) and Niemann-Pick C1 (
NPC1
) genes in an obese population in Saudi Arabia.
Methods
The genotypes of rs1800592, rs10011540 and rs3811791 (
UCP1
gene) and rs1805081 and rs1805082 (
NPC1
gene) were determined in a total of 492 subjects using TaqMan chemistry by Real-time PCR. In addition, capillary sequencing assay was performed to identify two specific polymorphisms viz., rs45539933 (exon 2) and rs2270565 (exon 5) of
UCP1
gene.
Results
A significant association of
UCP1
polymorphisms rs1800592 [OR, 1.52 (1.10–2.08);
p
= 0.009] was observed in the obese cohort after adjusting with age, sex and type 2 diabetes. Further BMI based stratification revealed that this association was inconsistent with both moderate and extreme obese cohort. A significant association of
UCP1
polymorphisms rs3811791 was observed only in the moderate-obese cohort [OR = 2.89 (1.33–6.25);
p
= 0.007] but not in the extreme-obese cohort indicating an overlying genetic complexity between moderate-obesity and extreme-obesity. The risk allele frequencies, which were higher in moderate-obese cohort, had abnormal HDL, LDL and triglyceride levels.
Conclusion
The rs1800592 and rs3811791 of
UCP1
gene are associated with obesity in general and in the moderate-obese group in particular. The associated
UCP1
polymorphisms in the moderate-obese group may regulate the impaired energy metabolism which plays a significant role in the initial stages of obesity.
Publisher
BioMed Central,BMC
Subject
/ Alleles
/ Biomedical and Life Sciences
/ Carrier Proteins - metabolism
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - diagnosis
/ Diabetes Mellitus, Type 2 - genetics
/ Diabetes Mellitus, Type 2 - metabolism
/ Diabetes Mellitus, Type 2 - physiopathology
/ Female
/ Genes
/ Genetic epidemiology and genetic associations
/ Genetic Predisposition to Disease
/ HDL
/ Humans
/ Insulin
/ Male
/ Membrane Glycoproteins - genetics
/ Membrane Glycoproteins - metabolism
/ Mutation
/ NCP1
/ Obesity
/ Patients
/ Proteins
/ Risk
/ UCP1
/ Uncoupling Protein 1 - genetics
