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Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
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Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
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Journal Article
Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
2011
Overview
Memory B cells formed in response to microbial antigens provide immunity to later infections; however, the inability to detect rare endogenous antigen-specific cells limits current understanding of this process. Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swig) or retained IgM. The more numerous lgM⁺ cells were longer lived than the swlg⁺ cells. However, swig⁺ memory cells dominated the secondary response because of the capacity to become activated in the presence of neutralizing serum immunoglobulin. Thus, we propose that memory relies on swig⁺ cells until they disappear and serum immunoglobulin falls to a low level, in which case memory resides with durable IgM⁺ reserves.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
ADP-ribosyl Cyclase 1 - analysis
/ Analysis of the immune response. Humoral and cellular immunity
/ Animals
/ Antigens
/ B-Lymphocyte Subsets - immunology
/ Biological and medical sciences
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Germinal Center - immunology
/ Immunoglobulin Class Switching
/ Immunoglobulin M - immunology
/ Male
/ Memory
/ Mice
/ Mutation
/ Organs and cells involved in the immune response
/ Spleen
