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Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers
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Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers
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Journal Article
Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers
2020
Overview
Self-stabilizing biodegradable microcarriers were produced via an oil/water solvent evaporation technique using amphiphilic chitosan-g-polyester copolymers as a core material in oil phase without the addition of any emulsifier in aqueous phase. The total yield of the copolymer-based microparticles reached up to 79 wt. %, which is comparable to a yield achievable using traditional emulsifiers. The kinetics of microparticle self-stabilization, monitored during their process, were correlated to the migration of hydrophilic copolymer’s moieties to the oil/water interface. With a favorable surface/volume ratio and the presence of bioadhesive natural fragments anchored to their surface, the performance of these novel microcarriers has been highlighted by evaluating cell morphology and proliferation within a week of cell cultivation in vitro.
Publisher
MDPI AG,MDPI
