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Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells

by Dellagostin, Odir A , e Lacerda, Rodrigo Rodrigues , Reis, Larissa B , Santi-Gadelha, Tatiane , Monte, Leonardo G , Prietsch, Rafael F , Braganhol, Elizandra , Gadelha, Carlos A. A , Conceição, Fabricio R , Pinto, Luciano S

in Abelmoschus / Abelmoschus - chemistry / Abelmoschus esculentus / analysis / Antineoplastic Agents / Antineoplastic Agents - isolation & purification / Antineoplastic Agents - pharmacology / Apoptosis / Applied Microbiology / Biochemistry / Biomedical and Life Sciences / Biotechnology / Breast / Breast cancer / breast neoplasms / Cancer / caspase-3 / caspase-9 / Caspases / Caspases - analysis / cell death / cell growth / Cell Line, Tumor / Charge coupled devices / chemistry / drug effects / Epithelial Cells / Epithelial Cells - drug effects / Epithelial Cells - physiology / Fibroblasts / Fibroblasts - drug effects / Fibroblasts - physiology / flow cytometry / genes / growth retardation / Human / Humans / isolation & purification / Lectins / Lectins - isolation & purification / Lectins - pharmacology / Life Sciences / Microbiology / Okra / Original Research Paper / pharmacology / physiology / Phytochemicals

2014

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Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells

2014

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Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells

2014

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Journal Article

Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells

Dellagostin, Odir A,

e Lacerda, Rodrigo Rodrigues,

Reis, Larissa B,

Santi-Gadelha, Tatiane,

Monte, Leonardo G,

Prietsch, Rafael F,

Braganhol, Elizandra,

Gadelha, Carlos A. A,

Conceição, Fabricio R,

Pinto, Luciano S

2014

Overview

The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer.

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Publisher

Springer-Verlag,Springer Netherlands,Springer Nature B.V

Subject

Abelmoschus

/ Abelmoschus - chemistry

/ Abelmoschus esculentus

/ analysis

/ Antineoplastic Agents

/ Antineoplastic Agents - isolation & purification

/ Antineoplastic Agents - pharmacology