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Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
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Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
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Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
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Journal Article
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
2017
Overview
Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.
Publisher
The Company of Biologists Ltd,The Company of Biologists
Subject
Adaptive Immunity - drug effects
/ Animals
/ Cardiomyopathy, Dilated - chemically induced
/ Cardiomyopathy, Dilated - complications
/ Cardiomyopathy, Dilated - immunology
/ Cardiomyopathy, Dilated - physiopathology
/ Disease
/ Edema
/ Female
/ Heart
/ Imidazoles - adverse effects
/ Immunity, Cellular - drug effects
/ Male
/ Myocarditis - chemically induced
/ Myocarditis - physiopathology
/ Skin
/ Toll-Like Receptor 7 - agonists
/ Toll-Like Receptor 7 - metabolism
