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Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
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Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
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Journal Article
Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
2016
Overview
World Health Organization is concerned for parental vitamin deficiency and its effect on offspring health. This study examines the effect of a marginally dietary-induced parental one carbon (1-C) micronutrient deficiency on embryonic gene expression using zebrafish. Metabolic profiling revealed a reduced 1-C cycle efficiency in F
0
generation. Parental deficiency reduced the fecundity and a total of 364 genes were differentially expressed in the F
1
embryos. The upregulated genes (53%) in the deficient group were enriched in biological processes such as immune response and blood coagulation. Several genes encoding enzymes essential for the 1-C cycle and for lipid transport (especially apolipoproteins) were aberrantly expressed. We show that a parental diet deficient in micronutrients disturbs the expression in descendant embryos of genes associated with overall health and result in inherited aberrations in the 1-C cycle and lipid metabolism. This emphasises the importance of parental micronutrient status for the health of the offspring.
Publisher
Nature Publishing Group,Nature Publishing Group UK
Subject
/ 38
/ 38/91
/ 49/47
/ 49/90
/ 64/116
/ 82/16
/ 82/58
/ Animals
/ Apolipoproteins - biosynthesis
/ Apolipoproteins - immunology
/ Embryos
/ Enzymes
/ Female
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Lipid Metabolism - immunology
/ Lipids
/ Male
/ Science
