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Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents
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Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents
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Journal Article
Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents
2014
Overview
It has been known for approximately 30 years that large doses of the semi-essential basic amino acid L-arginine induce severe pancreatic inflammation in rats. Recently, it has been demonstrated that L-arginine can also induce pancreatitis in mice. Moreover, other basic amino acids like L-ornithine and L-lysine can cause exocrine pancreatic damage without affecting the endocrine parenchyma and the ducts in rats. The utilization of these noninvasive severe basic amino acid-induced pancreatitis models is becoming increasingly popular and appreciated as these models nicely reproduce most laboratory and morphological features of human pancreatitis. Consequently, the investigation of basic amino acid-induced pancreatitis may offer us a better understanding of the pathogenesis and possible treatment options of the human disease.
Publisher
Elsevier Inc,Nature Publishing Group US,Nature Publishing Group
