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High prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate
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High prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate
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Journal Article
High prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate
2021
Overview
Multi-drug-resistance (MDR) is a severe public health concern worldwide, and its containment is more challenging in developing countries due to poor antimicrobial resistance (AMR) surveillance and irrational use of antibiotics. The current study investigated 100 clinical
E. coli
isolates and revealed that 98% of them were MDR. PCR analysis using 25 selected isolates showed the predominance of metallo-β-lactamase gene
bla
NDM
(80%) and ESBL genes
bla
OXA
(48%) and
bla
CTX-M-15
(32%). The AmpC gene was detected in 68% of the isolates, while 32% was
tet
C positive. Notably, 34% of the isolates were resistant to carbapenem. Whole genome sequence (WGS) analysis of an extensively drug-resistant (XDR) isolate (L16) revealed the presence of the notorious sequence type 131 responsible for multi-drug-resistant infections, multiple antibiotic resistance genes (ARGs), virulence genes, and mobile genetic elements that pose risks to environmental transmission. Our results indicate that MDR is alarmingly increasing in Bangladesh that critically limits the treatment option against infections and contributes to further aggravation to the prevailing situation of MDR worldwide. The findings of this study will be valuable in designing sustainable strategies to contain MDR in the region.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/1647
/ 631/208
/ 631/326
/ 631/337
/ 631/45
/ 692/420
/ Anti-Bacterial Agents - therapeutic use
/ Bacterial Proteins - genetics
/ Drug Resistance, Multiple, Bacterial - genetics
/ E coli
/ Escherichia coli - drug effects
/ Escherichia coli - isolation & purification
/ Escherichia coli Infections - diagnosis
/ Escherichia coli Infections - drug therapy
/ Escherichia coli Infections - epidemiology
/ Escherichia coli Infections - microbiology
/ Escherichia coli Proteins - genetics
/ Genes
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ LDCs
/ Science
