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A user-friendly herbicide derived from photo-responsive supramolecular vesicles
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A user-friendly herbicide derived from photo-responsive supramolecular vesicles
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A user-friendly herbicide derived from photo-responsive supramolecular vesicles
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Journal Article
A user-friendly herbicide derived from photo-responsive supramolecular vesicles
2018
Overview
Paraquat, as one of the most widely used herbicides globally, is highly toxic to humans, and chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we report user-friendly, photo-responsive paraquat-loaded supramolecular vesicles, prepared via one-pot self-assembly of amphiphilic, ternary host-guest complexes between cucurbit[8]uril, paraquat, and an azobenzene derivative. In this vesicle formulation, paraquat is only released upon UV or sunlight irradiation that converts the azobenzene derivative from its
trans
- to its
cis
- form, which in turn dissociates the ternary host-guest complexations and the vesicles. The cytotoxicity evaluation of this vesicle formulation of paraquat on in vitro cell models, in vivo zebrafish models, and mouse models demonstrates an enhanced safety profile. Additionally, the PQ-loaded vesicles’ herbicidal activity against a model of invasive weed is nearly identical to that of free paraquat under natural sunlight. This study provides a safe yet effective herbicide formulation.
Paraquat is a widely used herbicide that is highly toxic to humans upon acute ingestion or chronic exposure. Here, the authors generate a photosensitive formulation that releases paraquat upon exposure to UV light or sunlight, which shows an improved safety profile in zebrafish and mouse models, while maintaining substantial herbicidal activity.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/21
/ 13/31
/ 14
/ 14/19
/ 14/34
/ 140/131
/ 147/135
/ 59
/ 64
/ 64/116
/ 64/60
/ 706/1143
/ Animals
/ Azo Compounds - radiation effects
/ Female
/ Herbicides - radiation effects
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Paraquat
/ Paraquat - radiation effects
/ Science
/ Sunlight
/ Toxicity
/ Vesicles
