Journal Article

A generative network model of neurodevelopmental diversity in structural brain organization

Bullmore, Edward T., Vértes, Petra E., Astle, Duncan E., Akarca, Danyal

2021

Overview

The formation of large-scale brain networks, and their continual refinement, represent crucial developmental processes that can drive individual differences in cognition and which are associated with multiple neurodevelopmental conditions. But how does this organization arise, and what mechanisms drive diversity in organization? We use generative network modeling to provide a computational framework for understanding neurodevelopmental diversity. Within this framework macroscopic brain organization, complete with spatial embedding of its organization, is an emergent property of a generative wiring equation that optimizes its connectivity by renegotiating its biological costs and topological values continuously over time. The rules that govern these iterative wiring properties are controlled by a set of tightly framed parameters, with subtle differences in these parameters steering network growth towards different neurodiverse outcomes. Regional expression of genes associated with the simulations converge on biological processes and cellular components predominantly involved in synaptic signaling, neuronal projection, catabolic intracellular processes and protein transport. Together, this provides a unifying computational framework for conceptualizing the mechanisms and diversity in neurodevelopment, capable of integrating different levels of analysis—from genes to cognition. The formation of large-scale brain networks represents crucial developmental processes that can drive individual differences in cognition and which are associated with multiple neurodevelopmental conditions. Here, the authors use generative network modelling to provide a computational framework for understanding neurodevelopmental diversity.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 59/57 / 631/378/116/1925 / 631/378/2571/1696 / 631/553/2712 / 692/617/375/366 / Adolescent / Biological activity / Brain / Brain - diagnostic imaging / Brain - growth & development / Brain architecture / Child / Child Development - physiology / Cognition / Cognition & reasoning / Cognition - physiology / Cohort Studies / Computational neuroscience / Computer Simulation / Embedding / Female / Gene expression / Genes / Humanities and Social Sciences / Humans / Intracellular signalling / Iterative methods / Magnetic Resonance Imaging / Male / Mathematical models / Models, Neurological / multidisciplinary / Nerve Net - diagnostic imaging / Nerve Net - growth & development / Neural networks / Neurodevelopment / Neurodiversity / Neurogenesis - physiology / Parameters / Protein transport / Science / Science (multidisciplinary) / Steering / Wiring