Asset Details
Do you wish to reserve the book?
Gene interfered-ferroptosis therapy for cancers
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Gene interfered-ferroptosis therapy for cancers
Do you wish to request the book?
Gene interfered-ferroptosis therapy for cancers
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Gene interfered-ferroptosis therapy for cancers
2021
Overview
Although some effective therapies have been available for cancer, it still poses a great threat to human health and life due to its drug resistance and low response in patients. Here, we develop a ferroptosis-based therapy by combining iron nanoparticles and cancer-specific gene interference. The expression of two iron metabolic genes (
FPN
and
LCN2
) was selectively knocked down in cancer cells by Cas13a or microRNA controlled by a NF-κB-specific promoter. Cells were simultaneously treated by iron nanoparticles. As a result, a significant ferroptosis was induced in a wide variety of cancer cells. However, the same treatment had little effect on normal cells. By transferring genes with adeno-associated virus and iron nanoparticles, the significant tumor growth inhibition and durable cure were obtained in mice with the therapy. In this work, we thus show a cancer therapy based on gene interference-enhanced ferroptosis.
Improved therapeutic strategies are needed as drug resistance limits the therapeutic efficacy of several clinically approved cancer therapeutics. Here, the authors report a ferroptosis-based therapy using a combination of iron nanoparticles with gene interference to knockdown iron metabolic genes, FPN and LCN2.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 42/44
/ 42/89
/ Animals
/ Cancer
/ Cation Transport Proteins - antagonists & inhibitors
/ Cation Transport Proteins - genetics
/ Cation Transport Proteins - metabolism
/ CRISPR-Associated Proteins - genetics
/ CRISPR-Associated Proteins - metabolism
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Humanities and Social Sciences
/ Humans
/ Iron
/ Lipocalin-2 - antagonists & inhibitors
/ Mice
/ miRNA
/ Nanoparticles - administration & dosage
/ Reactive Oxygen Species - agonists
/ Reactive Oxygen Species - metabolism
/ RNA
/ Science
/ Therapy
