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Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
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Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
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Journal Article
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
2021
Overview
Inflammation generally leads to recruitment of monocyte-derived macrophages. What regulates the fate of these cells and to what extent they can assume the identity and function of resident macrophages is unclear. Here, we show that macrophages elicited into the peritoneal cavity during mild inflammation persist long-term but are retained in an immature transitory state of differentiation due to the presence of enduring resident macrophages. By contrast, severe inflammation results in ablation of resident macrophages and a protracted phase wherein the cavity is incapable of sustaining a resident phenotype, yet ultimately elicited cells acquire a mature resident identity. These macrophages also have transcriptionally and functionally divergent features that result from inflammation-driven alterations to the peritoneal cavity micro-environment and, to a lesser extent, effects of origin and time-of-residency. Hence, rather than being predetermined, the fate of inflammation-elicited peritoneal macrophages seems to be regulated by the environment.
The peritoneal cavity is a complicated myeloid niche containing a mixed population of resident macrophages and infiltrating cells that are responsive to inflammatory cues. Here the authors trace the fate of these infiltrating macrophages, their conversion to resident cells and how this is altered by the local inflammatory state over time.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 38/39
/ 38/90
/ 64/60
/ Ablation
/ Animals
/ Cell Differentiation - genetics
/ Female
/ GATA6 Transcription Factor - genetics
/ GATA6 Transcription Factor - metabolism
/ Humanities and Social Sciences
/ Macrophages, Peritoneal - cytology
/ Macrophages, Peritoneal - metabolism
/ Male
/ Mice
/ Peritoneal Cavity - pathology
/ Science
