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Highly Sensitive, Engineered Magnetic Nanosensors to Investigate the Ambiguous Activity of Zika Virus and Binding Receptors
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Highly Sensitive, Engineered Magnetic Nanosensors to Investigate the Ambiguous Activity of Zika Virus and Binding Receptors
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Journal Article
Highly Sensitive, Engineered Magnetic Nanosensors to Investigate the Ambiguous Activity of Zika Virus and Binding Receptors
2017
Overview
The aim of this research is twofold: 1) to shed light on zika’s binding and entry mechanism while 2) demonstrating the effectiveness of our magnetic relaxation platform to achieve this goal. Magnetic relaxation-sensitive nanoparticles (MRNPs) are used in a novel fashion to analyze binding interactions between the zika envelope protein (ZENV) and proposed host cell receptors: AXL, HSP70, and TIM-1. Computational analysis is also utilized to examine these binding interactions for the first time. In addition, the role of crizotinib as a potential binding inhibitor is demonstrated and the possibility of ligand-independent phosphatidylserine-mediated binding is explored. Our findings suggest that while the extracellular domain of AXL has the highest affinity for ZENV; HSP70, TIM-1, and phosphatidylserine might also play active roles in zika tropism, which offers a potential explanation for the variety of zika-associated symptoms. This is, to our knowledge, the first time that MRNPs have been used to examine and quantify host-zika interactions. Our magnetic relaxation platform allows for timely and sensitive analysis of these intricate binding relationships, and it is easily customizable for further examination of additional host-pathogen interactions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ 692/699
/ Axl Receptor Tyrosine Kinase
/ Biosensing Techniques - methods
/ Ferric Compounds - chemistry
/ Humanities and Social Sciences
/ Humans
/ Magnetite Nanoparticles - chemistry
/ Phosphatidylserines - chemistry
/ Phosphatidylserines - metabolism
/ Proto-Oncogene Proteins - chemistry
/ Proto-Oncogene Proteins - metabolism
/ Receptor Protein-Tyrosine Kinases - chemistry
/ Receptor Protein-Tyrosine Kinases - metabolism
/ Receptors, Virus - chemistry
/ Receptors, Virus - metabolism
/ Science
/ Tropism
