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Reveals of quercetin’s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation
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Reveals of quercetin’s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation
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Journal Article
Reveals of quercetin’s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation
2022
Overview
Oral lichen planus (OLP) is a localized autoimmune disease of the oral mucosa, with an incidence of up to 2%. Although corticosteroids are the first-line treatment, they cause several adverse effects. Quercetin, a naturally occurring compound, has fewer side-effects and provides long-term benefits. Besides, it has powerful anti‑inflammatory activities. Here, we combined network pharmacology with experimental verification to predict and verify the key targets of quercetin against OLP. First, 66 quercetin-OLP common targets were analyzed from various databases. The protein–protein interaction (PPI) network was constructed. Topology analysis and MCODE cluster analysis of common targets were conducted to identify 12 key targets including TP53, IL-6 and IFN-γ and their connections. Gene functions and key signaling pathways, including reactive oxygen species metabolism, IL-17 pathway and AGE-RAGE pathway, were enriched by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-γ to modulate the immune system in treating OLP. Quercetin considerably affected the apoptosis and migration of T lymphocytes in OLP patients. Our study reveals the potential therapeutic targets and signaling pathways of quercetin associated with OLP, and establishes the groundwork for future clinical applications.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Cell Movement - drug effects
/ Disease
/ Drug Evaluation, Preclinical
/ Female
/ Gene Regulatory Networks - drug effects
/ Gene Regulatory Networks - immunology
/ Genes
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Lichen Planus, Oral - drug therapy
/ Lichen Planus, Oral - immunology
/ Lichen Planus, Oral - pathology
/ Male
/ Mucosa
/ Ontology
/ Protein Interaction Maps - drug effects
/ Protein Interaction Maps - genetics
/ Protein Interaction Maps - immunology
/ Proteins
/ Reactive Oxygen Species - metabolism
/ Science
/ Steroids
/ T-Lymphocytes - drug effects
/ Th1-Th2 Balance - drug effects
/ Topology
