Journal Article

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Lu, Wei, Li, Kan, Chen, Lin, Faye, Ndeye Rokhaya, Kim, Jae-Hwan, Huang, Yonggang, Bai, Wubin, Han, Mengdi, Zhao, Hangbo, Model, Jeffrey B., Yang, Guanjun, Liu, Clifford, Efimov, Igor R., Sun, Bohan, Song, Enming, Ghaffari, Roozbeh, Rogers, John A., Ma, Yuhang, Liang, Cunman, Yang, Quansan, Aras, Kedar, Lee, Yujin, Chen, Xuexian, Baek, Janice Mihyun

2020

Overview

The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes. Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 631/1647/1453/1448 / 639/166/985 / 639/301/1005/1007 / 692/4019/2776 / Ablation / Actuation / Animal models / Animals / Arrays / Balloon catheters / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Biomedicine / Cardiac Catheters / Catheter Ablation / Catheters / Contact pressure / Density / Electric contacts / Electrical stimuli / Electronics - instrumentation / Electroporation / Equipment Design / Female / Finite Element Analysis / Heart / Heart surgery / Heart Ventricles - surgery / Humans / Monitoring, Intraoperative - instrumentation / Monitoring, Intraoperative - methods / Multilayers / Multiplexing / Pressure / Rabbits / Radio frequency / Radiofrequency ablation / Surgery / Surgical instruments / Temperature